Insulin is very important armamentarium in the management of diabetes mellitus.
Why insulin analogs –
Insulin therapy should mimic physiological insulin secretion (Basal & Bolus). Conventional insulins
don’t mimic physiological secretion, often resulting in mismatch between requirement and
availability with inadequate glycaemic control & late hypoglycaemia.
An insulin analog mimcs physiological endogenous insulin secretion
An insulin analog is an altered form of insulin, different from the conventional insulin, but
performing the same action in terms of glycemic control . Through genetic engineering of the
underlying DNA, the amino acid sequence of insulin can be changed to alter its ADME (absorption,
distribution, metabolism and excretion) characteristics
INSULIN ANALOGS – DR. D.P. KHAITAN
