Insulin is very important armamentarium in the management of diabetes mellitus.
Why insulin analogs –
 Insulin therapy should mimic physiological insulin secretion (Basal & Bolus). Conventional insulins
don’t mimic physiological secretion, often resulting in mismatch between requirement and
availability with inadequate glycaemic control & late hypoglycaemia.
 An insulin analog mimcs physiological endogenous insulin secretion
 An insulin analog is an altered form of insulin, different from the conventional insulin, but
performing the same action in terms of glycemic control . Through genetic engineering of the
underlying DNA, the amino acid sequence of insulin can be changed to alter its ADME (absorption,
distribution, metabolism and excretion) characteristics

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